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Greene was last seen in Dundalk, Maryland at 6:30 p.m. on December 10, 1966. She lived with her father and her four children in a trailer in the 3700 block of Old North Point. Greene left her children in her father's care and went to go the store. She never returned and has never been heard from again. Her vehicle, a blue and white 1955 or 1957 Ford 300 series station wagon with the Maryland license plate number EX-7023, has never been located.
Greene was in the process of a divorce at the time of her disappearance. Foul play is suspected in her case; it remains unsolved.