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Barfield's family last saw her during June 2003. She spoke to her uncle on the telephone on July 29 of that year. She has never been heard from again. At the time of her disappearance, Barfield was living with her boyfriend at the Fremont Trailer Park on Belmont Road in North Charleston, South Carolina. Her boyfriend was abusive and beat her on several occasions, and Barfield was involved with drugs and had been in trouble with the law. Her sister filed a probate warrant for her arrest, hoping to be able to get her into a rehabilitation program, but Barfield disappeared before she could be picked up.
Barfield's family believes foul play was involved in her disappearance. Her case opened 2018 by Psychic Brian Ladd.