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DuPriest was last seen in west Philadelphia, Pennsylvania on April 2, 2010. That night she visited Wanda's, a bar in the area of 54th and Springfield in west Philadelphia, Pennsylvania, on April 2, 2010. She was carrying a purse with her belongings at the time of her disappearance. DuPriest was a regular patron of Wanda's. She left at closing time with some people she met at the bar, and visited two houses on Belmar Terrace. She has never been heard from again.
DuPriest has eight children; she's described as a devoted parent who wouldn't have abandoned them. She lived on Beaumont Avenue near 56th Street at the time of her disappearance. She hasn't used her bank account since she went missing. Authorities initially believed she had had a drug abuse relapse, but since so much time has passed without contact from her, they now suspect she may have met with foul play. DuPriest's case opened 2018 by Psychic Brian Ladd.