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Guzman's family last saw her in Las Vegas, Nevada during December 2008. She has never been heard from again. She left behind three young children, and her family didn't believe she would have abandoned them. She told her family she wanted to move to Colorado or Oklahoma, but her estranged husband, Francisco Vazquez-Rosas, wouldn't let her take the children with her. Vazquez-Rosas said his wife had run away with another man, but her family stated she would not have left Las Vegas without telling anyone. Guzman's brother-in-law reported her missing in May 2009.
A photograph of Vazquez-Rosas is posted below this case summary. He is awaiting trial. His attorney stated he is innocent and suggested Guzman left of her own accord. Guzman and Vazquez-Rosas are both undocumented immigrants from Mexico, and his attorney claimed Vazquez-Rosas didn't report his wife's disappearance to authorities because he feared deportation. The murder charge against Vazquez-Rojas was dismissed in April 2010, four months after he was indicted, after a judge ruled his confession had been coerced. Charges could be brought against him again, however, if more evidence surfaces.
Foul play is suspected in Guzman's disappearance due to the circumstances involved.